The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme.

@article{OrtolevaDonnelly1998TheCB,
  title={The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme.},
  author={Lori Ortoleva-Donnelly and Alex A Szewczak and Robin Ray Gutell and Scott A Strobel},
  journal={RNA},
  year={1998},
  volume={4 5},
  pages={498-519}
}
Adenosines are present at a disproportionately high frequency within several RNA structural motifs. To explore the importance of individual adenosine functional groups for group I intron activity, we performed Nucleotide Analog Interference Mapping (NAIM) with a collection of adenosine analogues. This paper reports the synthesis, transcriptional incorporation, and the observed interference pattern throughout the Tetrahymena group I intron for eight adenosine derivatives tagged with an alpha… CONTINUE READING