The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition.

@article{Goldstein1994TheCR,
  title={The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition.},
  author={Steve A. N. Goldstein and Deborah J. Pheasant and Christopher Miller},
  journal={Neuron},
  year={1994},
  volume={12 6},
  pages={1377-88}
}
Charybdotoxin (CTX) is a peptide of known structure that inhibits Shaker K+ channels by a pore-blocking mechanism. Point mutagenesis of all 30 solvent-exposed residues identified the part of the CTX molecular surface making contact with the receptor in the K+ channel. All close-contact residues are clustered in a well-defined interaction surface; the shape of this surface implies that the outer opening of the Shaker channel conduction pore abruptly widens to a 25 x 35 A plateau. A mutagenic… CONTINUE READING
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