The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in β-amyloid peptide toxicity.

@article{CachoValadez2012TheCO,
  title={The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in β-amyloid peptide toxicity.},
  author={Briseida Cacho-Valadez and Fernando Mu{\~n}oz-Lobato and Jos{\'e} Rafael Pedrajas and Juan M. Cabello and Juan Carlos Fierro-Gonz{\'a}lez and Pl{\'a}cido Navas and Peter Swoboda and Chris D Link and Antonio Miranda-Vizuete},
  journal={Antioxidants & redox signaling},
  year={2012},
  volume={16 12},
  pages={
          1384-400
        }
}
AIM Functional in vivo studies on the mitochondrial thioredoxin system are hampered by the embryonic or larval lethal phenotypes displayed by murine or Drosophila knock-out models. Thus, the access to alternative metazoan knock-out models for the mitochondrial thioredoxin system is of critical importance. RESULTS We report here the characterization of the mitochondrial thioredoxin system of Caenorhabditis elegans that is composed of the genes trx-2 and trxr-2. We demonstrate that the proteins… CONTINUE READING

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