The characterization of a zebrafish mid‐hindbrain mutant, mid‐hindbrain gone (mgo)

@article{Shima2009TheCO,
  title={The characterization of a zebrafish mid‐hindbrain mutant, mid‐hindbrain gone (mgo)},
  author={Takaki Shima and Wade A. Znosko and Michael Tsang},
  journal={Developmental Dynamics},
  year={2009},
  volume={238}
}
The vertebrate mid‐hindbrain boundary (MHB) is a crucial morphological structure required for patterning and neural differentiation of the midbrain and anterior hindbrain. We isolated a novel zebrafish mutant, MHB gone (mgo), that exhibited a defective MHB. Expression of engrailed3 in the prospective MHB was absent at the 1‐somite stage, suggesting that initiation of the isthmic organizer was disrupted in mgo mutants. Complementation test with mgo and noi, in which the pax2a gene is mutated… Expand
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