The characterization and function of human immunoregulatory T lymphocyte subsets.

Abstract

Functional T lymphocyte subpopulations can be identified in humans by antibodies which detect stable glycoprotein antigens on their surface. Thus, inducer T lymphocytes bear an antigen termed T4 while suppressor T lymphocytes bear an antigen termed T5. Immune homeostasis results from a delicate balance between inducer and suppressor subsets within the T-cell circuit and perturbation in subset dynamics may initiate a wide variety of immunopathological disorders. Here Ellis Reinherz and Stuart Schlossman discuss the present understanding of this circuit, its role in the pathogenesis of a number of diseases and how the human immune response can be manipulated in an orderly way through modulation of selected T-cell subsets.

DOI: 10.1016/0167-5699(81)90019-0

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@article{Reinherz1981TheCA, title={The characterization and function of human immunoregulatory T lymphocyte subsets.}, author={E. L. Reinherz and Stuart F. Schlossman}, journal={Pharmacological reviews}, year={1981}, volume={34 1}, pages={17-22} }