The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine

@article{Church1983TheCO,
  title={The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine},
  author={M. Church and K. D. Young},
  journal={British Journal of Pharmacology},
  year={1983},
  volume={78}
}
1 Three drugs have been tested for activity against antigen‐induced histamine release from passively sensitized human lung fragments after increasing periods of pre‐incubation before challenge. 2 After 30 s pre‐incubation, sodium cromoglycate inhibited histamine release in the concentration range 0.2–200 μm, producing a maximum inhibition of 33.0%. As the pretreatment period was extended, tolerance developed in a dose‐related manner, resulting in a 48.3% and 82.8% loss of activity of the 200 μm… Expand
Inhibition profiles of sodium cromoglycate and nedocromil sodium on mediator release from mast cells of human skin, lung, tonsil, adenoid and intestine
Bronchorelaxation and plasma histamine after salbutamol inhalation
The pharmacology and mechanisms of action of histamine H1‐antagonists
  • S. Rimmer, M. Church
  • Medicine
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1990
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
The inhibition by disodium cromoglycate in vitro of anaphylactically induced histamine release from rat peritoneal mast cells.
Inhibition of immediate hypersensitivity reactions by disodium cromoglycate.
The mechansim of tachyphylaxis to ICI 74,917 and disodium cromoglycate.
Drug-induced changes in the release and uptake of biogenic amines. A study on mast cells.
...
1
2
3
4
5
...