The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine

@article{Church1983TheCO,
  title={The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine},
  author={M. Church and K. D. Young},
  journal={British Journal of Pharmacology},
  year={1983},
  volume={78}
}
1 Three drugs have been tested for activity against antigen‐induced histamine release from passively sensitized human lung fragments after increasing periods of pre‐incubation before challenge. 2 After 30 s pre‐incubation, sodium cromoglycate inhibited histamine release in the concentration range 0.2–200 μm, producing a maximum inhibition of 33.0%. As the pretreatment period was extended, tolerance developed in a dose‐related manner, resulting in a 48.3% and 82.8% loss of activity of the 200 μm… Expand
Nedocromil sodium inhibits antigen‐induced contraction of human lung parenchymal and bronchial strips, and the release of sulphidopeptide‐leukotrienes and histamine from human lung fragments
TLDR
The therapeutic effects of nedocromil sodium in allergic asthma may depend, partly, on its inhibition of antigen‐induced release of leukotrienes and histamine in human lung and its consequent inhibition of antibody-induced contractions of parenchymal and bronchial tissue. Expand
Inhibition of IgE‐dependent histamine release from human dispersed lung mast cells by anti‐allergic drugs and salbutamol
TLDR
The results suggest that salbutamol is a more effective inhibitor of mediator release from human lung mast cells than anti‐allergic drugs, and both sal butamol and SCG are likely to be effective inhibitors of both preformed and newly generated mediators. Expand
Histamine secretion from human skin slices induced by anti‐IgE and artificial secretagogues and the effects of sodium cromoglycate and salbutamol
TLDR
Human cutaneous mast cells show functional differences from their counterparts in other tissues and passive sensitization with 10% atopic serum increased the secretory response to anti‐IgE but histamine release was only concentration related over the entire 1/1000 to 1/10 dilution range in half of the specimens studied. Expand
Pulmonary anti-anaphylactic activity of clenbuterol tested on actively and passively sensitized guinea-pigs.
TLDR
Clen buterol and isoprenaline inhibited the release of histamine and of thromboxane A2 triggered by ovalbumin injected into isolated lungs from actively sensitized guinea-pigs indicating that the anti-anaphylactic properties of clenbuterol are independent from its smooth muscle relaxing activity. Expand
Inhibition of histamine release from dispersed human lung and tonsillar mast cells by nicardipine and nifedipine.
TLDR
The observations demonstrate that nicardipine and nifedipine inhibit IgE-dependent and ionophore stimulated mediator secretion from human mast cells, suggesting that inhibition of mast cell mediator release is unlikely to be the mechanism by which these drugs alleviate asthma. Expand
Differential Effects of β2-Adrenoceptor Desensitization on the IgE-Dependent Release of Chemical Mediators from Cultured Human Mast Cells
In the present study, we examined the inhibitory effects of the β2-adrenoceptor agonists isoproterenol, salbutamol, fenoterol, and clenbuterol, on the release of chemical mediators from culturedExpand
Effect of salbutamol, fenoterol, and sodium cromoglycate on the release of heparin from sensitized human lung fragments challenged with Dermatophagoides pteronyssinus allergen.
TLDR
The beta 2-agonists salbutamol and fenoterol strongly inhibited heparin release from mast cells and the therapeutic use of mast cell stabilizing agents may be potentially detrimental to the control of allergic inflammation and other associated pathologies. Expand
Inhibition profiles of sodium cromoglycate and nedocromil sodium on mediator release from mast cells of human skin, lung, tonsil, adenoid and intestine
TLDR
The results confirm that high concentrations of sodium cromoglycate and nedocromil sodium are required to achieve even modest inhibition of mediator release from human mast cells under in vitro conditions, and indicate that differences exist among skin, lung, tonsillar, adenoidal and intestinal mast cells with respect to their sensitivity to salt. Expand
Bronchorelaxation and plasma histamine after salbutamol inhalation
TLDR
It is suggested that histamine may be released and sequestered within the lungs during carbachol-induced-bronchospasm, and also that desequestration of bronchoconstrictor mediators accumulated at the point of contact ofBronchial smooth muscle may contribute to the relief of bronChospasm by salbutamol. Expand
The pharmacology and mechanisms of action of histamine H1‐antagonists
  • S. Rimmer, M. Church
  • Medicine
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1990
TLDR
Several studies have demonstrated elevated baseline plasma histamine in stable asthma, the level of which may relate to the severity of the airways obstruction, suggesting the presence of a background 'histamine tone' possibly due to a continuous release of histamine by activated mast cells or basophils. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
THE ACTIVITY OF SODIUM CROMOGLYCATE ANALOGUES IN HUMAN LUNG in vitro: A COMPARISON WITH RAT PASSIVE CUTANEOUS ANAPHYLAXIS AND CLINICAL EFFICACY
TLDR
The human lung model is not predictive of anti‐asthmatic activity in man as the six analogues tested clinically are less effective than sodium cromoglycate, and these results throw doubt on the use of models of mast cell degranulation in the search for Antiallergic drugs and, possibly, on the relative importance of mastcell degranulations in the pathogenesis of asthma. Expand
The inhibition by disodium cromoglycate in vitro of anaphylactically induced histamine release from rat peritoneal mast cells.
TLDR
It is suggested that DSCG acts indirectly, inducing the formation of an unstable species in mast cells from a precursor present in a limited amount, using rat peritoneal mast cells as an example. Expand
INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS
1 A series of cationic, lipophilic histamine H1‐receptor antagonists, neuroleptics, antidepressants and monoamine oxidase inhibitors were tested for their effects on anti‐IgE‐induced histamineExpand
Inhibition by Sympathomimetic Amines of Histamine Release induced by Antigen in Passively Sensitized Human Lung
THE release of histamine after the application of antigen to a sensitized tissue provides a readily measurable index of the occurrence of a cellular anaphylactic reaction, while inhibition of theExpand
Passive anaphylaxis in human lung fragments as a model for testing anti-allergic drugs: its variability and constraints.
TLDR
Although theoretically a very appropriate model of allergic asthma, passive anaphylaxis in human lung fragments is quantitatively inconsistent and gives only a gross indication of drug efficacy. Expand
A COMPARISON OF THE ANTI‐ANAPHYLACTIC ACTIVITIES OF SALBUTAMOL AND DISODIUM CROMOGLYCATE IN THE RAT, THE RAT MAST CELL AND IN HUMAN LUNG TISSUE
TLDR
It is suggested that salbutamol may be more effective in allergic asthma if given in a prophylactic regimen and disodium cromoglycate was a weak inhibitor of the anaphylactic release of histamine and SRS‐A from fragments of human lung. Expand
Inhibition of the release of histamine from rat mast cells: the effect of cold and adrenergic drugs on release of histamine by compound 48-80 and antigen.
  • A. Johnson, N. Moran
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1970
TLDR
The inhibition by drugs of the selective histamine releasing agents, antigen and 48/80, could be related to any known adrenergic mechanisms but release of histamine by Triton X-100 was not inhibited by any of the drugs tested. Expand
Inhibition of immediate hypersensitivity reactions by disodium cromoglycate.
TLDR
It is suggested that disodium cromoglycate may act by releasing some factor capable of inhibiting the release of mediators from the mast cell as well as inhibit IgE-mediated cutaneous anaphylaxis in the rat in vivo and release of histamine from peritoneal mast cells in vitro. Expand
The mechansim of tachyphylaxis to ICI 74,917 and disodium cromoglycate.
TLDR
Pre-incubation in vitro of sensitised peritoneal mast cells for 10 min with either ICI 74,917 or disodium cromoglycate abolished the ability of either drug to inhibit histamine release when subsequently presented to the cells at the same time as antigen. Expand
Drug-induced changes in the release and uptake of biogenic amines. A study on mast cells.
TLDR
The investigations show that the effects of tricyclic neuroleptics and antidepressants on mast cells are the consequences of changes in permeability, and a significant correlation between the Hi releasing potency and the lipophilic nature of the drugs. Expand
...
1
2
3
4
5
...