The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats.

@article{Dai2005TheCO,
  title={The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats.},
  author={Chengkai Dai and Yelena Lyustikman and Alan Shih and Xiaoyi Hu and Gregory N Fuller and Marc K. Rosenblum and Eric C. Holland},
  journal={Neoplasia},
  year={2005},
  volume={7 4},
  pages={397-406}
}
Chronic platelet-derived growth factor (PDGF) signaling in glial progenitors leads to the formation of oligodendrogliomas in mice, whereas chronic combined Ras and Akt signaling leads to astrocytomas. Different histologies of these tumors imply that the pathways activated by these two oncogenic stimulations are different, and that the apparent lineage of the tumor cells may result from specific signaling activity. Therefore, we have investigated the signaling effects of PDGF in culture and in… CONTINUE READING
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