The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes

  title={The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes},
  author={Reiko Uenoyama and Tamako Miyazaki and Jane L. Hurst and Robert J. Beynon and Masaatsu Adachi and Takanobu Murooka and Ibuki Onoda and Yuki Miyazawa and Rieko Katayama and Tetsuro Yamashita and Shuji Kaneko and Toshio Nishikawa and Masao Miyazaki},
  journal={Science Advances},
Cats anoint themselves with plant metabolites that confer mosquito repellence. Domestic cats and other felids rub their faces and heads against catnip (Nepeta cataria) and silver vine (Actinidia polygama) and roll on the ground as a characteristic response. While this response is well known, its biological function and underlying mechanism remain undetermined. Here, we uncover the neurophysiological mechanism and functional outcome of this feline response. We found that the iridoid nepetalactol… 
3 Citations
Folklore, Animal Self-Medication, and Phytotherapy-Something Old, Something New, Something Borrowed, Some Things True.
14 case studies of purported animal-inspired plant medicines used by cultures around the world are presented together with ethnomedicinal and pharmacological evidence and a role for animal self-medication research in the rejuvenation of old therapies and possible new discoveries of phytotherapies for human and livestock health is encouraged.
The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies
Psychopharmacological evidence is examined to outline the role of the mu-opioid receptor (MOR) system in the processing of threat and reward, and discuss how disruption of these processes by chronic opioid use might alter emotional learning and reward responsiveness.
The irritant receptor TRPA1 mediates the mosquito repellent effect of catnip
The results support the use of catnip and nepetalactone as insect-selective irritants and suggest that, despite TRPA1's broad conservation, insect TRPA 1 can be targeted for the development of safe repellents.


Responsiveness of cats (Felidae) to silver vine (Actinidia polygama), Tatarian honeysuckle (Lonicera tatarica), valerian (Valeriana officinalis) and catnip (Nepeta cataria)
Olfactory enrichment for cats may have great potential, and silver vine and Tatarian honeysuckle appear to be good alternatives to catnip for domestic cats that do not respond toCatnip.
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  • Biology, Medicine
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Catnip often produces a distinct avoidance response in young kittens which is gradually replaced by indifference in non-responders and by heightened curiosity in responders, and the response is not manifested in kittens under six to eight weeks of age and may not develop fully until three months of age.
Anointing Chemicals and Hematophagous Arthropods: Responses by Ticks and Mosquitoes to Citrus (Rutaceae) Peel Exudates and Monoterpene Components
The results support the notion that anointing by vertebrates with citrus-derived chemicals deters ticks and suggest that some topically applied compounds are converted into more potent arthropod deterrents when oxidized on the integument of anointed animals.
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Repellent activity of the essential oil of the catmint plant, Nepeta cataria, and the main iridoid compounds, was assessed against major Afro-tropical pathogen vector mosquitoes, revealing not only a synergistic effect between the two, but also a surprising ratio-dependent effect, with lower activity for the pure isomers and equivalent or near-equivalent mixtures, but higher activity for non-equ equivalents.
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It was quantitatively demonstrated that catnip responsiveness is not limited to the domestic cat, that it is notlimited to the female, and that it varies dramatically between species and age of felids.
Seasonal Anointment with Millipedes in a Wild Primate: A Chemical Defense Against Insects?
It is argued that the secretion that rubs off on the monkeys in the course of anointment provides protection against insects, particularly mosquitoes (and the bot flies they transmit) during the rainy season.
Adult Repellency and Larvicidal Activity of Five Plant Essential Oils Against Mosquitoes
Thyme oil had the highest effectiveness in repelling this species, but the repellency duration was only 2 h, and catnip oil seemed to be the most effective and provided 6-h protection at both concentrations tested.
The evolutionary origins of the cat attractant nepetalactone in catnip
Insight is provided into the interplay between enzyme and genome evolution in the origins, loss, and re-emergence of plant chemical diversity in the Nepeta lineage.
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Most drugs and several environmental, physio­ logic, and psychologic factors altered the response qualitatively and peripheral nicotinic and central muscarinic cholinoceptive and serotonergic facilitation of the catnip response, with a prominent voluntary component, indicated.
Plant-Based Natural Product Chemistry for Integrated Pest Management of Drosophila suzukii
An investigation of plant-based chemistry, where natural compounds that are structurally similar to known olfactory cues from parasitoid wasps that in turn are well-described ovipositional avoidance cues for many Drosophila species are searched for.