The chaperone function: meanings and myths.

  title={The chaperone function: meanings and myths.},
  author={Peter A. Lund and Ross J Ellis},
  journal={Novartis Foundation symposium},
  pages={23-36; discussion 36-44, 137-40}
What are molecular chaperones and how should we think about them? We propose that it is better to think in terms of a chaperone function rather than in terms of chaperone molecules. We define the chaperone function as the prevention or reversal of incorrect interactions that may occur when reactive macromolecular surfaces are transiently exposed to the intracellular environment. We suggest that this function is a distinct and essential cellular function, mediated by many different proteins… CONTINUE READING