The channel-kinase TRPM7, revealing the untold story of Mg(2+) in cellular signaling.

Abstract

Ion homeostasis dysregulations have severe effects on human health, impairing the effectiveness and appropriateness of major cellular events, including immune responses. The adverse effects of Mg(2+) deficiency on cellular physiology are well known and documented, but mechanistic insights into Mg(2+) sensitive signal transduction are still lacking. TRPM7… (More)
DOI: 10.1684/mrh.2014.0357

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