The changing spectrum of drug-induced immune hemolytic anemia.

  title={The changing spectrum of drug-induced immune hemolytic anemia.},
  author={Patricia A Arndt and George Garratty},
  journal={Seminars in hematology},
  volume={42 3},
Drug-induced immune hemolytic anemia (DIIHA) occurs rarely. To date, about 100 drugs have been implicated in causing DIIHA and/or a positive direct antiglobulin test (DAT). The most common drugs associated with DIIHA in the 1970s were methyldopa and penicillin; currently, they are cefotetan and ceftriaxone. Drug antibodies fall into two types: drug-independent ("autoantibodies") and drug-dependent ("penicillin type" or "immune complex type"); some patients have combinations of these antibodies… CONTINUE READING


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