The changing scene of neurotrophic factors.

  title={The changing scene of neurotrophic factors.},
  author={Hans Thoenen},
  journal={Trends in neurosciences},
  volume={14 5},
The purification of brain-derived neurotrophic factor (BDNF), the elucidation of its primary structure, and the subsequent identification of neurotrophin-3 (NT-3) ended the monopoly of NGF as the only well-characterized, target-derived neurotrophic molecule. NGF, BDNF and NT-3 are members of a gene family called neurotrophins. They have strictly conserved domains that determine their basic structure. However, they also have distinctly variable domains that determine their different neuronal… CONTINUE READING

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