The changing scene of amyotrophic lateral sclerosis

  title={The changing scene of amyotrophic lateral sclerosis},
  author={W. Robberecht and T. Philips},
  journal={Nature Reviews Neuroscience},
  • W. Robberecht, T. Philips
  • Published 2013
  • Medicine
  • Nature Reviews Neuroscience
  • Several recent breakthroughs have provided notable insights into the pathogenesis of amyotrophic lateral sclerosis (ALS), with some even shifting our thinking about this neurodegenerative disease and raising the question as to whether this disorder is a proteinopathy, a ribonucleopathy or both. In addition, these breakthroughs have revealed mechanistic links between ALS and frontotemporal dementia, as well as between ALS and other neurodegenerative diseases, such as the cerebellar atrophies… CONTINUE READING
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