The changing picture of amyotrophic lateral sclerosis: lessons from European registers

@article{Hardiman2017TheCP,
  title={The changing picture of amyotrophic lateral sclerosis: lessons from European registers},
  author={Orla Hardiman and Ammar Al-Chalabi and Carol Brayne and Ettore Beghi and Leonard H. van den Berg and Adriano Chi{\`o} and Sarah Martin and Giancarlo Logroscino and James Rooney},
  journal={Journal of Neurology, Neurosurgery, and Psychiatry},
  year={2017},
  volume={88},
  pages={557 - 563}
}
Prospective population based-registers of amyotrophic lateral sclerosis (ALS) have operated in Europe for over two decades, and have provided important insights into our understanding of ALS. Here, we review the benefits that population registers have brought to the understanding of the incidence, prevalence, phenotype and genetics of ALS and outline the core operating principles that underlie these registers and facilitate international collaboration. Going forward, we offer lessons learned… 

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