The changing face of acromegaly—advances in diagnosis and treatment

  title={The changing face of acromegaly—advances in diagnosis and treatment},
  author={Ant{\^o}nio Ribeiro-Oliveira and Ariel L Barkan},
  journal={Nature Reviews Endocrinology},
Acromegaly is a chronic disease characterized by the presence of a pituitary growth hormone (GH)-producing tumour, excessive secretion of growth hormone, raised levels of insulin-like growth factor I (IGF-I) and characteristic clinical presentation of acral enlargement. Over the past two decades, major advances have occurred in the understanding of some aspects of acromegaly—such as the biology of pituitary tumours, the physiology, molecular mechanisms of GH secretion and IGF-I generation, and… CONTINUE READING
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