The changing epidemiology of diphtheria in the vaccine era.
@article{Galazka2000TheCE, title={The changing epidemiology of diphtheria in the vaccine era.}, author={Artur M. Galazka}, journal={The Journal of infectious diseases}, year={2000}, volume={181 Suppl 1}, pages={ S2-9 } }
The epidemic of diphtheria in the Newly Independent States (NIS) of the former Soviet Union has drawn attention to our incomplete understanding of the epidemiology of diphtheria. Many unanswered questions remain concerning the reasons for a resurgence of diphtheria and for the shift in the age of patients and concerning the mechanisms for acquisition of immunity in adults through natural infection under unfavorable living conditions. Other unanswered questions relate to the precise role of…
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References
SHOWING 1-10 OF 109 REFERENCES
Current situation and control strategies for resurgence of diphtheria in newly independent states of the former Soviet Union
- Medicine, Political ScienceThe Lancet
- 1996
A diphtheria epidemic in Lesotho, 1989. Did vaccination increase the population's susceptibility?
- MedicineAnnals of tropical paediatrics
- 1993
It is suggested that the number of throat carriers, who in the absence of skin diphtheria would provide most of the population's immunity, decreases as an indirect consequence of vaccination, and that certain groups not immediately reached by vaccination become more susceptible to diphTheria.
Diphtheria in the former Soviet Union: reemergence of a pandemic disease.
- MedicineEmerging infectious diseases
- 1998
Factors contributing to the epidemic included a large population of susceptible adults; decreased childhood immunization, which compromised what had been a well-established childhood vaccination program; suboptimal socioeconomic conditions; and high population movement.
Status of antitoxic immunity against diphtheria in Japan. A report of the National Epidemiological Surveillance for Important Communicable Diseases.
- MedicineJapanese journal of medical science & biology
- 1983
The data show clearly that the successful control of diphtheria has been accomplished in Japan as the result of active immunization, and indicate that the continuous surveillance for diphTheria is required in this country.
The changing age structure of diphtheria patients: evidence for the effectiveness of EPI in the Sudan.
- MedicineBulletin of the World Health Organization
- 1990
Results indicate that improved vaccination coverage led to the shift in the age distribution of diphtheria patients seen during the 1988 outbreak, and can be used as a simple way of assessing the effectiveness of the Expanded Programme on Immunization (EPI).
Immunity to diphtheria and tetanus in some of the administrative territories of the RSFSR
- Medicine
- 1984
An essential drop in the level of immunity to diphtheria in persons over 18 years of age was revealed: 71.7% of them were nonimmune, which correlated with the high morbidity rate among these persons.
Implications of the diphtheria epidemic in the Former Soviet Union for immunization programs.
- MedicineThe Journal of infectious diseases
- 2000
It is important to achieve a high level of childhood immunization, maintain immunity against diphtheria in older age groups, and use anti-epidemic measures, including Immunization, to control epidemics in the early phase.
Susceptibility to diphtheria among elderly persons; immunization by the intracutaneous administration of toxoid.
- MedicineThe New England journal of medicine
- 1952
THIS study attempts to evaluate the incidence of susceptibility to diphtheria and the sensitivity to diphtheria toxoid among elderly persons. In addition, a pilot study on a method of immunizing…
Epidemiological features of an outbreak of diphtheria and its control with diphtheria toxoid immunization.
- MedicineInternational journal of epidemiology
- 1992
An outbreak of diphtheria primarily involving adults occurred in seven townships and one farm in Jiangling county, Hubei, China from September 1988 to January 1989, following which the incidence declined rapidly.
The changing epidemiology of diphtheria in Jordan.
- MedicineBulletin of the World Health Organization
- 1988
Contrary to the findings in previous diphtheria epidemics in Jordan, this outbreak largely involved adolescents and young adults.