The changing concepts in the neuropathology of acquired demyelinating central nervous system disorders

@article{Lassmann2019TheCC,
  title={The changing concepts in the neuropathology of acquired demyelinating central nervous system disorders},
  author={Hans Lassmann},
  journal={Current Opinion in Neurology},
  year={2019},
  volume={32},
  pages={313–319}
}
  • H. Lassmann
  • Published 1 June 2019
  • Biology, Medicine
  • Current Opinion in Neurology
Purpose of review Research on multiple sclerosis (MS) pathogenesis and therapy is to a large extent driven by results obtained in experimental autoimmune encephalomyelitis (EAE). This approach provided deep insights into the mechanism of brain inflammation and immune mediated tissue injury and, thus, most of our currently established therapies for MS patients have been developed with profound contributions of experimental autoimmune research. Recent data, which are summarized in this review… 
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Background Experimental autoimmune encephalomyelitis (EAE) is a model for inflammatory demyelinating diseases of the central nervous system (CNS), a group of autoimmune diseases characterized by
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TLDR
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Metabolic determinants of leukocyte pathogenicity in neurological diseases
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The role of intracellular metabolic cues in regulating leukocyte‐mediated CNS damage in Alzheimer's and Parkinson's disease, multiple sclerosis and stroke is discussed, highlighting the therapeutic potential of drugs targeting metabolic pathways for the treatment of neurological diseases.
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