The changing clinical spectrum of primary aldosteronism.

  title={The changing clinical spectrum of primary aldosteronism.},
  author={Emmanuel L Bravo and Robert C. Tarazi and Harriet P. Dustan and Fetnat M. Fouad and Stephen C. Textor and Ray W. Gifford and Donald G. Vidt},
  journal={The American journal of medicine},
  volume={74 4},
In a prospective study of 80 patients with primary aldosteronism (70 with adenoma and 10 with hyperplasia), "refractory" hypertension, hyperkinetic circulation, and hypovolemia were frequent occurrences. We found that measurements of serum potassium concentration and plasma renin activity were inadequate screening tests because of high rates of false-positive and false-negative results. The demonstration of excessive aldosterone production after three days of salt loading provided the best… CONTINUE READING


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