The change of antizyme inhibitor expression and its possible role during mammalian cell cycle.

@article{Murakami2009TheCO,
  title={The change of antizyme inhibitor expression and its possible role during mammalian cell cycle.},
  author={Yasuko Murakami and Jun-ichiro Suzuki and Keijiro Samejima and Kenjiro Kikuchi and Tomasz Hascilowicz and Noriyuki Murai and Senya Matsufuji and Takami Oka},
  journal={Experimental cell research},
  year={2009},
  volume={315 13},
  pages={2301-11}
}
Antizyme inhibitor (AIn), a homolog of ODC, binds to antizyme and inactivates it. We report here that AIn increased at the G1 phase of the cell cycle, preceding the peak of ODC activity in HTC cells in culture. During interphase AIn was present mainly in the cytoplasm and turned over rapidly with the half-life of 10 to 20 min, while antizyme was localized in the nucleus. The level of AIn increased again at the G2/M phase along with ODC, and the rate of turn-over of AIn in mitotic cells… CONTINUE READING