The challenges posed by cancer heterogeneity

  title={The challenges posed by cancer heterogeneity},
  author={Sangeeta N. Bhatia and John V. Frangioni and Robert M Hoffman and A. John Iafrate and Kornelia Polyak},
  journal={Nature Biotechnology},
A panel of five experts discuss the implications of cancer heterogeneity for diagnostics and therapy. 

The evolving role of multi-gene tests in breast cancer management.

If MGTs could predict which patients were most prone to late recurrence and thus might benefit from extended adjuvant endocrine therapy, it would be a huge advancement in the care and survivorship of

Intratumor heterogeneity: origins, clinical significance and optimal strategies for cancer treatment.

1st Division of General Surgery, Department of Human Morphology & Surgical Sciences, Insubria University Varese-Como, Italy Department of Surgery Ioannina University Hospital, Ioannina, Greece

Extracellular Matrix Heterogeneity Regulates Three‐Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion

This work successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.

Cancer heterogeneity is not compatible with one unique cancer cell metabolic map

It is concluded that there is no one metabolic map of cancer but several and the two extremes of a panel from the hypoxic to the normoxic state are described.

A Model-System to Address the Impact of Phenotypic Heterogeneity and Plasticity on the Development of Cancer Therapies

In vitro model-systems that consist of several genetically-related but phenotypically distinct populations can be used as proxies for the several phenotypes present in a patient with advanced disease to address the potential impact of phenotypic heterogeneity and plasticity of cancer on the development of successful therapies.

The Evolving Role of MultiGene Tests in Breast Cancer Management

The current review by Drs. Zelnak and O’Regan aptly summarizes multi-gene tests (MGTs), their prognostic role, and how gene expression profiling has aided the definition of molecular breast cancer

Clinical Applications and Anticancer Effects of Antimicrobial Peptides: From Bench to Bedside

The structure, biological function, and underlying mechanisms of AMPs are presented and the recent experimental studies and clinical trials on anticancer peptides in different cancer types as well as the challenges of their clinical application are discussed.

Understanding tumor heterogeneity as an encourager for cancer metastasis (in vitro model of tumor heterogeneity)

A in vitro tumor heterogeneity model, capable of emulating 3D microenvironment and heterogeneous condition of tumor, is developed to evaluate the phenotypic phenomena caused in heterogeneous cell population in tumor during metastasis.

Nanotechnology for cancer screening and diagnosis

This review presents the advantages of nanomaterials used in these platforms and introduces the various nanotechnology-based biosensing and imaging techniques that are improving screening and diagnosis of cancers.



Firms combine experimental cancer drugs to speed development

The next generation of cancer treatments could be approved in pairs, at least judging by a growing trend among drug makers to combine drugs early in development and the US Food and Drug Administration’s willingness to regulate them.