The challenge of viral reservoirs in HIV-1 infection.

  title={The challenge of viral reservoirs in HIV-1 infection.},
  author={Joel N Blankson and Deborah Persaud and Robert F. Siliciano},
  journal={Annual review of medicine},
A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reservoirs for HIV-1. It is now clear that HIV-1 persists in a small reservoir of latently infected resting memory CD4(+) T cells, which shows minimal decay even in patients on highly… CONTINUE READING
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