The challenge of identification of autoantibodies specific to systemic autoimmune rheumatic diseases in high throughput operation: proposal of reliable and feasible strategies.

@article{Pereira2014TheCO,
  title={The challenge of identification of autoantibodies specific to systemic autoimmune rheumatic diseases in high throughput operation: proposal of reliable and feasible strategies.},
  author={Kaline Medeiros Costa Pereira and Alessandra Dellavance and L E Coelho Andrade},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2014},
  volume={437},
  pages={
          203-10
        }
}
BACKGROUND Autoantibodies to extractable nuclear antigens (ENA) are good biomarkers for systemic autoimmune rheumatic diseases (SARD), but no one assay for the detection of these antibodies provides satisfactory sensitivity and positive predictive value (PPV). Here we evaluate current assays and propose novel strategies to detect anti-ENA antibodies. METHODS Diagnostic performance of double immunodiffusion (DID) and several enzyme immunoassays (EIA) for the detection of anti-ENA… CONTINUE READING
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