The challenge of Down syndrome.

  title={The challenge of Down syndrome.},
  author={Stylianos E. Antonarakis and Charles J. Epstein},
  journal={Trends in molecular medicine},
  volume={12 10},
Down syndrome (DS) has been recognized as a clinical entity for about 150 years, but it is only recently that there has been hope for the possibility to understand its pathogenesis and to use this information to devise approaches for the prevention and treatment of its numerous features. The earlier pessimism was due to several reasons, including: (i) the nature of the genetic defect that leads to the syndrome; (ii) the multiplicity of systems involved; and (iii) the high degree of variability… CONTINUE READING

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