The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells.

@article{Gergely2003TheCP,
  title={The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells.},
  author={Fanni Gergely and Viji M Draviam and Jordan W Raff},
  journal={Genes & development},
  year={2003},
  volume={17 3},
  pages={336-41}
}
The ch-TOG/XMAP215 family of proteins bind directly to microtubules and appear to play an essential role in stabilizing spindle microtubules. These proteins stabilize microtubules mainly by influencing microtubule plus-end dynamics, yet, in vivo, they are all strongly concentrated at spindle poles, where the minus ends of the microtubules are concentrated. In Drosophila embryos, the centrosomal protein D-TACC is required to efficiently recruit ch-TOG/Msps to centrosomes. In humans, ch-TOG and… CONTINUE READING
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