The cerebrovascular permeability to protein after bicuculline and amphetamine administration in spontaneously hypertensive rats. Evidence for increased resistance of pressure-induced blood-brain barrier dysfunction.

@article{Johansson1977TheCP,
  title={The cerebrovascular permeability to protein after bicuculline and amphetamine administration in spontaneously hypertensive rats. Evidence for increased resistance of pressure-induced blood-brain barrier dysfunction.},
  author={Barbro Birgitta Johansson},
  journal={Acta neurologica Scandinavica},
  year={1977},
  volume={56 5},
  pages={397-404}
}
Hemodynamic and morphometric studies on spontaneously hypertensive rats (SHR) have suggested that the lumen to wall ratio of the resistance vessels is decreased due to hypertrophy of the media. As the tension in the vessel wall increases with the pressure and the radius and decreases with the vessel wall thickness, such vessels would be expected to withstand higher pressure than vessels of normotensive rats (NR) unless local wall defects were present. Bicuculline-induced epileptic activity and… CONTINUE READING

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