The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type.

Abstract

OBJECTIVE To evaluate the production rate of CSF in patients with differing disease states. METHODS The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven with dementia of the Alzheimer's type (AD) (aged 72 +/- 9 years, mean +/- SD). This method, based on the Masserman technique, employs ventricular rather than a lumbar access to the CSF space. Furthermore, the volume of CSF removed during the procedure is only 3 mL rather than 10 mL. RESULTS These measurements indicate that the mean rate of CSF production in patients with PD under age 60 was 0.47 +/- 0.13 mL/minute, in patients with PD aged 60 or older the mean rate was 0.40 +/- 0.12 mL/minute, and in patients with AD the mean rate was 0.20 +/- 0.06 mL/minute. CONCLUSION These results indicate that the rate of CSF production in patients with PD is normal, and that the rate of CSF production in patients with AD is markedly reduced.

Showing 1-10 of 44 extracted citations
0200400'04'05'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

1,749 Citations

Semantic Scholar estimates that this publication has received between 710 and 3,514 citations based on the available data.

See our FAQ for additional information.