The cerebrospinal fluid from patients with multiple sclerosis promotes neuronal and oligodendrocyte damage by delayed production of nitric oxide in vitro

@article{Xiao1996TheCF,
  title={The cerebrospinal fluid from patients with multiple sclerosis promotes neuronal and oligodendrocyte damage by delayed production of nitric oxide in vitro},
  author={Baoguo Xiao and Gai Xiu Zhang and Chun Guang Ma and Hans - J{\"u}rgen Link},
  journal={Journal of the Neurological Sciences},
  year={1996},
  volume={142},
  pages={114-120}
}
Nitric oxide (NO) may be involved in myelin and oligodendrocyte injury associated with multiple sclerosis (MS), a demyelinating disease of unknown etiology. The cerebrospinal fluid (CSF) from MS patients may provide an important signal inducing a pathologic process within the central nervous system (CNS). To investigate this question, CSF-induced NO production by glial cells was studied in 38 patients with multiple sclerosis (MS), 30 patients with other CNS inflammatory diseases (ID) and 20… CONTINUE READING
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