The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly.

@article{Walker2000TheCP,
  title={The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly.},
  author={Lary C Walker and Harry D. Levine},
  journal={Molecular neurobiology},
  year={2000},
  volume={21 1-2},
  pages={
          83-95
        }
}
The abnormal assembly and deposition of specific proteins in the brain is the probable cause of most neurodegenerative disease afflicting the elderly. These "cerebral proteopathies" include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), prion diseases, and a variety of other disorders. Evidence is accumulating that the anomalous aggregation of the proteins, and not a loss of protein function, is central to the pathogenesis of these diseases. Thus, therapeutic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Fluoro-Silane as a Functional Monomer for Protein Conformational Imprinting

VIEW 7 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration.

  • Translational research : the journal of laboratory and clinical medicine
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Similar Papers