The cerebellar network: From structure to function and dynamics

  title={The cerebellar network: From structure to function and dynamics},
  author={Egidio D’Angelo and Paolo Mazzarello and Francesca Prestori and Jonathan Mapelli and Sergio M. G. Solinas and Paola Lombardo and Elisabetta Cesana and Daniela Gandolfi and Luigi Congi},
  journal={Brain Research Reviews},

Figures from this paper

Neural circuits of the cerebellum: hypothesis for function.

It is suggested that the cerebellum can operate the realignment of temporally incongruent signals, allowing their binding and pattern recognition in Purkinje cells, providing a conceptual solution to the discrepancy between cerebellar learning and timing.

Computational Neuroscience of Timing, Plasticity and Function in Cerebellum Microcircuits

Simulations suggest plasticity at cerebellar relays may be an important element of tremendous storage capacity reliable in the learning of coordination of actions, sensorimotor or cognitive, in which the cerebellum participates.

Neuronal circuit function and dysfunction in the cerebellum: from neurons to integrated control.

This special issue follows the meeting The Cerebellum: From Neurons to Higher Control and Cognition and covers cerebellum neuronal circuit functions and synaptic plasticity, moving from neurons to integrated control and considering the potential causes of cerebellar ataxia and motor learning dysfunction.

Distributed Circuit Plasticity: New Clues for the Cerebellar Mechanisms of Learning

When the circuit embeds multiple forms of plasticity, it can easily cope with multiple behaviors endowing therefore the cerebellum with the properties needed to operate as an effective generalized forward controller.

The cerebellar network: revisiting the critical issues

As a fundamental aspect of the cerebellum, Rodolfo Llinas (Llinas, 2011) reviews here the dispute between cerebellar motor learning and cerebellAR motor timing, which is clearly fundamental and preliminary to the interpretation of Cerebellar circuit function.

Linking oscillations in cerebellar circuits

This work presents certain cerebellar oscillatory phenomena that have been recorded in rodents and primates, and reviews here how those oscillations are recorded, some of their modulatory mechanisms, and also identifies some of the Cerebellar nodes where they could interact.

Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition

It is proposed that the cerebellum operates as a general-purpose co-processor, whose effects depend on the specific brain centers to which individual modules are connected.

Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit

This paper takes as an example the cerebellar network, in which extensive investigations have revealed LTP and LTD at several excitatory and inhibitory synapses, and investigates the impact of their impact on network functioning in vivo.

Transient dynamics and rhythm coordination of inferior olive spatio-temporal patterns

This work builds a large scale IO network model of electrically coupled conductance-based neurons to study the emerging spatio-temporal patterns of its transient neuronal activity, and shows that the presence of regions with different excitability levels creates sinks and sources of coordinated activity which shape the propagation of spike wave fronts.



A Theory of Cerebellar Function

Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum

Recent electrophysiological experiments that have described a rich variety of use-dependent plasticity in cerebellum, including long-term potentiation (LTP) and LTD of excitatory and inhibitory synapses, and persistent modulation of intrinsic neuronal excitability are reviewed.

The Olivocerebellar System as a Generator of Temporal Patterns

It is proposed that interactions between the cerebellum and the inferior olive endow the system with the ability to generate complex temporal patterns, which can be used for fine adjustment of motor output, sensory expectation, or shifting attentions.

Model-Founded Explorations of the Roles of Molecular Layer Inhibition in Regulating Purkinje Cell Responses in Cerebellar Cortex: More Trouble for the Beam Hypothesis

  • J. Bower
  • Biology
    Front. Cell. Neurosci.
  • 2010
This paper outlines how model-based studies are changing the authors' thinking about the role of feed-forward molecular layer inhibition in the cerebellar cortex and suspects that inhibition may play a much more complex, subtle, and central role in the physiological and functional organization of cerebellary cortex.

Timing in the cerebellum: oscillations and resonance in the granular layer

Combinatorial responses controlled by synaptic inhibition in the cerebellum granular layer.

High-resolution voltage-sensitive dye imaging techniques show that simultaneous activation of two partially overlapping mossy fiber bundles can cause combined excitation and combined inhibition, which are compatible with the concepts of coincidence detection and spatial pattern separation predicted by theory.

Dynamic organization of motor control within the olivocerebellar system

The results support the view that the inferior olive organizes movement in time, by entraining motor-neuronal firing through rhythmic activation of the cerebellum, and in space, by synchronously activating cell ensembles that allow the use of individual muscles.

The Functional Equivalence of Ascending and Parallel Fiber Inputs in Cerebellar Computation

The data support theories of cerebellar computation that consider granule cell inputs to be functionally comparable, and the activity of Purkinje cells was significantly increased upon stimulation of lateral granule cells in vivo.