The cerebellar network: From structure to function and dynamics

@article{DAngelo2011TheCN,
  title={The cerebellar network: From structure to function and dynamics},
  author={Egidio D’Angelo and Paolo Mazzarello and Francesca Prestori and Jonathan Mapelli and Sergio M. G. Solinas and Paola Lombardo and Elisabetta Cesana and Daniela Gandolfi and Luigi Congi},
  journal={Brain Research Reviews},
  year={2011},
  volume={66},
  pages={5-15}
}

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References

SHOWING 1-10 OF 141 REFERENCES

A Theory of Cerebellar Function

Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum

Recent electrophysiological experiments that have described a rich variety of use-dependent plasticity in cerebellum, including long-term potentiation (LTP) and LTD of excitatory and inhibitory synapses, and persistent modulation of intrinsic neuronal excitability are reviewed.

The Olivocerebellar System as a Generator of Temporal Patterns

It is proposed that interactions between the cerebellum and the inferior olive endow the system with the ability to generate complex temporal patterns, which can be used for fine adjustment of motor output, sensory expectation, or shifting attentions.

Model-Founded Explorations of the Roles of Molecular Layer Inhibition in Regulating Purkinje Cell Responses in Cerebellar Cortex: More Trouble for the Beam Hypothesis

  • J. Bower
  • Biology
    Front. Cell. Neurosci.
  • 2010
This paper outlines how model-based studies are changing the authors' thinking about the role of feed-forward molecular layer inhibition in the cerebellar cortex and suspects that inhibition may play a much more complex, subtle, and central role in the physiological and functional organization of cerebellary cortex.

Timing in the cerebellum: oscillations and resonance in the granular layer

Combinatorial responses controlled by synaptic inhibition in the cerebellum granular layer.

High-resolution voltage-sensitive dye imaging techniques show that simultaneous activation of two partially overlapping mossy fiber bundles can cause combined excitation and combined inhibition, which are compatible with the concepts of coincidence detection and spatial pattern separation predicted by theory.

Dynamic organization of motor control within the olivocerebellar system

The results support the view that the inferior olive organizes movement in time, by entraining motor-neuronal firing through rhythmic activation of the cerebellum, and in space, by synchronously activating cell ensembles that allow the use of individual muscles.

Précis of Neural organization: Structure, function, and dynamics

The claim that language and other cognitive processes can be fruitfully studied within the framework of neural organization that the authors have charted with John Szentágothai is concluded.
...