The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program

@article{Schmidt2010TheCP,
  title={The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program},
  author={Susanne I. Schmidt and Leonid Schneider and Frank Essmann and Ion Cristian Cirstea and Fabian Kuck and Anja Kletke and Reiner U. J{\"a}nicke and Constanze Wiek and Helmut Hanenberg and Mohammad Reza Ahmadian and Klaus Schulze-Osthoff and B. Meinecke N{\"u}rnberg and Roland P. Piekorz},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={6184-6192}
}
Microtubule-interfering cancer drugs such as paclitaxel (PTX) often cause chemoresistance and severe side effects, including neurotoxicity. To explore potentially novel antineoplastic molecular targets, we investigated the cellular response of breast carcinoma cells to short hairpin(sh)RNA-mediated depletion of the centrosomal protein transforming acidic coiled coil (TACC) 3, an Aurora A kinase target expressed during mitosis. Unlike PTX, knockdown of TACC3 did not trigger a cell death response… CONTINUE READING
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