The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer.

@article{Hayward2004TheCK,
  title={The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer.},
  author={Daniel Geoffrey Hayward and Robert B. Clarke and Alison J. Faragher and M. Radhakrishna Pillai and Iain M Hagan and Andrew M Fry},
  journal={Cancer research},
  year={2004},
  volume={64 20},
  pages={7370-6}
}
Aneuploidy and chromosome instability are common abnormalities in human cancer. Loss of control over mitotic progression, multipolar spindle formation, and cytokinesis defects are all likely to contribute to these phenotypes. Nek2 is a cell cycle-regulated protein kinase with maximal activity at the onset of mitosis that localizes to the centrosome. Functional studies have implicated Nek2 in regulation of centrosome separation and spindle formation. Here, we present the first study of the… CONTINUE READING

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