The centrosomal component CEP161 of Dictyostelium discoideum interacts with the Hippo signaling pathway

@inproceedings{Sukumaran2015TheCC,
  title={The centrosomal component CEP161 of Dictyostelium discoideum interacts with the Hippo signaling pathway },
  author={Salil Kalarikkal Sukumaran and Rosemarie Blau-Wasser and Meino Rohlfs and Christoph Gallinger and Michael Schleicher and Angelika A. Noegel},
  booktitle={Cell cycle},
  year={2015}
}
CEP161 is a novel component of the Dictyostelium discoideum centrosome which was identified as binding partner of the pericentriolar component CP250. Here we show that the amino acids 1-763 of the 1381 amino acids CEP161 are sufficient for CP250 binding, centrosomal targeting and centrosome association. Analysis of AX2 cells over-expressing truncated and full length CEP161 proteins revealed defects in growth and development. By immunoprecipitation experiments we identified the Hippo related… CONTINUE READING

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