The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats

@article{Kawaura2009TheCA,
  title={The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats},
  author={Kazuaki Kawaura and Yukino Ogata and M. Inoue and S. Honda and K. Takahama},
  journal={Behavioural Brain Research},
  year={2009},
  volume={205},
  pages={315-318}
}
  • Kazuaki Kawaura, Yukino Ogata, +2 authors K. Takahama
  • Published 2009
  • Chemistry, Medicine
  • Behavioural Brain Research
  • The antidepressant-like effect of tipepidine was studied in rats. Tipepidine at 20 and 40 mg/kg i.p. reduced immobility in the forced swimming test and tipepidine at 40 mg/kg, i.p. increased climbing in the test. The drug at 40 mg/kg, i.p. had no effect on the locomotor activity and motor coordination. These results suggest that tipepidine may be a novel drug with antidepressant-like activity. 
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