The central vein sign in multiple sclerosis patients with vascular comorbidities

@article{Guisset2020TheCV,
  title={The central vein sign in multiple sclerosis patients with vascular comorbidities},
  author={François Guisset and Valentina Lolli and C{\'e}line Bugli and Gaetano Perrotta and Julie Absil and Bernard Dachy and Caroline Pot and Marie Th{\'e}audin and Marco Pasi and Vincent van Pesch and Pietro Maggi},
  journal={Multiple Sclerosis Journal},
  year={2020},
  volume={27},
  pages={1057 - 1065}
}
Background: The central vein sign (CVS) is an imaging biomarker able to differentiate multiple sclerosis (MS) from other conditions causing similar appearance lesions on magnetic resonance imaging (MRI), including cerebral small vessel disease (CSVD). However, the impact of vascular risk factors (VRFs) for CSVD on the percentage of CVS positive (CVS+) lesions in MS has never been evaluated. Objective: To investigate the association between different VRFs and the percentage of CVS+ lesions in MS… 
8 Citations
Central Vein Sign Profile of Newly Developing Lesions in Multiple Sclerosis: A 3-Year Longitudinal Study.
TLDR
In a cohort of adults with MS followed over a median duration of 3 years, most newly developing T2 or enhancing lesions were CVS+ (68%), and nearly half (48%) developed newCVS+ lesions only.
Central vein sign: A putative diagnostic marker for multiple sclerosis.
TLDR
The existing literature on CVS is reviewed to evaluate its added value in the diagnosis of MS and usefulness in differentiating it from other vasculopathies and identify available automated CVS assessment methods.
The Use of the Central Vein Sign in the Diagnosis of Multiple Sclerosis: A Systematic Review and Meta-analysis
TLDR
The meta-analysis performed shows that the use of the CVS in differentiating MS from other mimicking diseases is encouraged; moreover, theUse of dedicated sequences such as 3D-EPI and the high MRI field is beneficial.
Central vein sign and iron rim in multiple sclerosis: ready for clinical use?
TLDR
The assessment of the CVS and iron rim lesions is feasible in the clinical scenario and provides MRI measures specific to MS pathological substrates, improving diagnosis and prognosis of these patients.
Stronger Microstructural Damage Revealed in Multiple Sclerosis Lesions with Central Vein Sign by Quantitative Gradient Echo MRI
TLDR
Gradient Echo Plural Contrast Imaging (GEPCI) MRI is used to simultaneously visualize CVS and measure tissue damage in MS lesions to examine CVS in relation to tissue integrity in white matter lesions and among MS subtypes.
Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study
TLDR
Paramagnetic rim lesions, rare in other neurological conditions, yielded high specificity in differentiating MS from non‐MS, and future prospective multicenter studies should validate their role as a diagnostic biomarker.
Characteristics of secondary progressive multiple sclerosis: Disease activity and provision of care in Germany - A registry-based/multicentric cohort study.
TLDR
To assess the real-world situation in monitoring disease activity in SPMS patients and to identify associations of resulting subgroups with demographics, symptomatology, and therapy, the active, inactive, and unclassifiable patients were compared.
Walk Your Talk: Real-World Adherence to Guidelines on the Use of MRI in Multiple Sclerosis
TLDR
Although the MS community is getting closer to a standardization of MRI protocols, there is still a relatively wide heterogeneity among NR, with particular reference to contrast administration, which must be overcome to guarantee an adequate quality of patients’ care in MS.

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TLDR
A simplified determination of CVS in three white matter lesions on 3T FLAIR* MRI demonstrated good specificity and sensitivity and fair inter-rater reliability for a diagnosis of MS and with further study, may be a candidate for clinical application.
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