• DOI:10.1080/13813450701661198
Corpus ID: 35240599

The central role of glutathione in the pathophysiology of human diseases

@article{Franco2007TheCR,
  title={The central role of glutathione in the pathophysiology of human diseases},
  author={R. Franco and O. Schoneveld and Aglaia Pappa and M. Panayiotidis},
  journal={Archives Of Physiology And Biochemistry},
  year={2007},
  volume={113},
  pages={234 - 258}
}

R. Franco, O. Schoneveld, +1 author M. Panayiotidis

Published 2007

Biology, Medicine

Archives Of Physiology And Biochemistry

Abstract Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first, the formation of γ-glutamylcysteine from glutamate and cysteine, by the activity of the γ-glutamylcysteine synthetase; and second, the formation of GSH by the activity of GSH sythetase which uses γ-glutamylcysteine and glycine as substrates. While its synthesis and metabolism occur intracellularly, its… CONTINUE READING

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