The central role of glutathione in the pathophysiology of human diseases
@article{Franco2007TheCR, title={The central role of glutathione in the pathophysiology of human diseases}, author={R. Franco and O. Schoneveld and Aglaia Pappa and M. Panayiotidis}, journal={Archives Of Physiology And Biochemistry}, year={2007}, volume={113}, pages={234 - 258} }
Abstract Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first, the formation of γ-glutamylcysteine from glutamate and cysteine, by the activity of the γ-glutamylcysteine synthetase; and second, the formation of GSH by the activity of GSH sythetase which uses γ-glutamylcysteine and glycine as substrates. While its synthesis and metabolism occur intracellularly, its… CONTINUE READING
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References
SHOWING 1-10 OF 327 REFERENCES
Glutathione metabolism and its implications for health.
- Biology, Medicine
- The Journal of nutrition
- 2004
- 2,454
- Highly Influential
- PDF
The importance of glutathione in human disease.
- Biology, Medicine
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2003
- 1,425
The changing faces of glutathione, a cellular protagonist.
- Chemistry, Medicine
- Biochemical pharmacology
- 2003
- 1,034
- Highly Influential
- PDF
Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux
- Biology, Medicine
- Diabetologia
- 2004
- 120
- PDF
Regulation of glutathione in inflammation and chronic lung diseases.
- Biology, Medicine
- Mutation research
- 2005
- 86
Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy.
- Biology, Medicine
- Pharmacology & therapeutics
- 1991
- 862