The central role of glutathione in the pathophysiology of human diseases

  title={The central role of glutathione in the pathophysiology of human diseases},
  author={Rodrigo Franco and Onard J.L.M. Schoneveld and Aglaia Pappa and Mihalis I. Panayiotidis},
  journal={Archives Of Physiology And Biochemistry},
  pages={234 - 258}
Abstract Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first, the formation of γ-glutamylcysteine from glutamate and cysteine, by the activity of the γ-glutamylcysteine synthetase; and second, the formation of GSH by the activity of GSH sythetase which uses γ-glutamylcysteine and glycine as substrates. While its synthesis and metabolism occur intracellularly, its… 

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