The central role of glutathione in the pathophysiology of human diseases

  title={The central role of glutathione in the pathophysiology of human diseases},
  author={R. Franco and O. Schoneveld and Aglaia Pappa and M. Panayiotidis},
  journal={Archives Of Physiology And Biochemistry},
  pages={234 - 258}
  • R. Franco, O. Schoneveld, +1 author M. Panayiotidis
  • Published 2007
  • Biology, Medicine
  • Archives Of Physiology And Biochemistry
  • Abstract Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first, the formation of γ-glutamylcysteine from glutamate and cysteine, by the activity of the γ-glutamylcysteine synthetase; and second, the formation of GSH by the activity of GSH sythetase which uses γ-glutamylcysteine and glycine as substrates. While its synthesis and metabolism occur intracellularly, its… CONTINUE READING
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