The central role of glutathione in the pathophysiology of human diseases.

@article{Franco2007TheCR,
  title={The central role of glutathione in the pathophysiology of human diseases.},
  author={R Franco and Onard J.L.M. Schoneveld and Aglaia Pappa and Mihalis I Panayiotidis},
  journal={Archives of physiology and biochemistry},
  year={2007},
  volume={113 4-5},
  pages={
          234-58
        }
}
Reduced glutathione (L-gamma-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first, the formation of gamma-glutamylcysteine from glutamate and cysteine, by the activity of the gamma-glutamylcysteine synthetase; and second, the formation of GSH by the activity of GSH synthetase which uses gamma-glutamylcysteine and glycine as substrates. While its synthesis and metabolism occur… CONTINUE READING

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