The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation.

@article{Merla2007TheCR,
  title={The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation.},
  author={Ramanna Merla and Yumei Ye and Yu Lin and Saraswathy Manickavasagam and Ming-He Huang and Regino J. Perez-Polo and Barry F Uretsky and Yochai Birnbaum},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 3},
  pages={H1918-28}
}
  • Ramanna Merla, Yumei Ye, +5 authors Yochai Birnbaum
  • Published 2007 in
    American journal of physiology. Heart and…
Statins activate phosphatidylinositol-3-kinase, which activates ecto-5'-nucleotidase and phosphorylates 3-phosphoinositide-dependent kinase-1 (PDK-1). Phosphorylated (P-)PDK-1 phosphorylates Akt, which phosphorylates endothelial nitric oxide synthase (eNOS). We asked if the blockade of adenosine receptors (A(1), A(2A), A(2B), or A(3) receptors) could attenuate the induction of Akt and eNOS by atorvastatin (ATV) and whether ERK1/2 is involved in the ATV regulation of Akt and eNOS. In protocol 1… CONTINUE READING