The central role of FcεRI in allergy
@article{vonBubnoff2003TheCR, title={The central role of Fc$\epsilon$RI in allergy}, author={Dagmar von Bubnoff and Natalija Novak and Stefan Kraft and Thomas Bieber}, journal={Clinical and Experimental Dermatology}, year={2003}, volume={28} }
The high‐affinity receptor for immunoglobulin E (IgE), FcεRI, plays a central role in the initiation and control of atopic allergic inflammation. On mast cells and basophils, the function of the receptor is well known and constitutes cellular degranulation and the release of various mediators. FcεRI on antigen‐presenting cells (APCs), however, does not lead to degranulation of preformed granula, but has different functions: signal transduction pathways like the activation of NF‐κB are initiated…
52 Citations
Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm
- Biology, MedicineCellular and Molecular Life Sciences
- 2011
Various cellular and molecular mechanisms triggered through FcεRI/mast cell axis in allergy and anaphylaxis are discussed with a special emphasis on the functional genomics paradigm.
Natural products targeting FcεRI receptor for anti-allergic therapeutics.
- Biology, ChemistryJournal of food biochemistry
- 2020
The present contribution is mainly focused to describe natural products targeting FcεRI receptor and to emphasize their applicable potential as anti-allergic foods.
Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer
- BiologyExpert opinion on therapeutic targets
- 2005
This review summarises recent advances of FcR, which were mainly obtained by murine studies, and highlights novel antibodies as possible F cR-targeting therapies for allergy, autoimmune diseases and cancer.
The role of the high-affinity IgE receptor, FcepsilonRI, in eosinophilic gastrointestinal diseases.
- Medicine, BiologyImmunology and allergy clinics of North America
- 2009
Natural Killer Cells and the Skin
- Medicine, Biology
- 2010
Atopic individuals show an inherited dominance of TH2 responses, and blood T cells of these patients respond to allergens such as birch pollen allergen, with the production of Interleukin, IL-5, and IL-13 rather than Interferon (IFN)-γ (which is secreted by TH1 cells) as in healthy individuals.
Resveratrol Suppresses Cytokine Production Linked to FcεRI-MAPK Activation in IgE-Antigen Complex-Exposed Basophilic Mast Cells and Mice.
- Biology, MedicineThe American journal of Chinese medicine
- 2015
It was found that resveratrol mitigated the phosphorylation of p38 MAPK, ERK, and JNK elevated in mast cells exposed to Fc epsilon receptor I (FcεRI)-mediated immunoglobulin E (IgE)-antigen complex and may possess the therapeutic potential of targeting mast cells in preventing the development of allergic inflammation.
Different Stabilities of the Structurally Related Receptors for IgE and IgG on the Cell Surface Are Determined by Length of the Stalk Region in Their α-Chains1
- BiologyThe Journal of Immunology
- 2006
This work compared two structurally related Ig receptors, human FcεRI and FcγRIIIA, which carry different α-chains but the same γ-chains, and found that the stalk region was critical in determining the difference in their stability and ligand-induced up-regulation.
Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells.
- Biology, MedicineImmunity
- 2005
Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases.
- Biology, MedicineThe Journal of allergy and clinical immunology
- 2016
References
SHOWING 1-10 OF 29 REFERENCES
FcεRI-Mediated Activation of Transcription Factors in Antigen-Presenting Cells
- BiologyInternational Archives of Allergy and Immunology
- 2001
Data suggest a pathophysiological concept of an IgE-mediated delayed-type hypersensitivity reaction in atopic diseases, and the elucidation of further transcription factors involved in FcΕRI signaling in APC should contribute to the employment of new inhibition strategies for the treatment of atopic and other inflammatory diseases.
Fc epsilon ri-mediated activation of transcription factors in antigen-presenting cells.
- BiologyInternational archives of allergy and immunology
- 2001
Data suggest a pathophysiological concept of an IgE-mediated delayed-type hypersensitivity reaction in atopic diseases, and the elucidation of further transcription factors involved in Fc epsilon RI signaling in APC should contribute to the employment of new inhibition strategies for the treatment of atopic and other inflammatory diseases.
Fc epsilon RI on human epidermal Langerhans cells: an old receptor with new structure and functions.
- BiologyInternational archives of allergy and immunology
- 1997
Structural and functional analysis of the high-affinity receptor for IgE (Fc epsilonRI) on Langerhans cells (LCs) has highlighted new aspects of the biology of this structure when expressed on…
Engagement of FcεRI on Human Monocytes Induces the Production of IL-10 and Prevents Their Differentiation in Dendritic Cells1
- BiologyThe Journal of Immunology
- 2001
It is suggested that FcεRI aggregation prevents the generation of CD1a+ MoDCs and imply a novel pivotal function of this receptor in modulating the differentiation of monocytes.
Regulation of the high affinity receptor for IgE on human epidermal Langerhans cells.
- BiologyJournal of immunology
- 1998
These mechanisms enable LC to be highly versatile APCs by rapidly adapting the surface level of Fc epsilonRI to distinct inflammatory environments, which cannot be influenced by IL-4, IgE, or other agents.
Engagement of Fc epsilon RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells.
- BiologyJournal of immunology
- 2001
It is suggested that FcepsilonRI aggregation prevents the generation of CD1a(+) MoDCs and imply a novel pivotal function of this receptor in modulating the differentiation of monocytes.
A second amplifier function for the allergy-associated Fc(epsilon)RI-beta subunit.
- BiologyImmunity
- 2000
It is reported that beta has a second amplification function: the amplification of Fc(epsilon)RI cell surface expression, due to an early association of beta with alpha, resulting in improved trafficking and maturation of alpha and receptor complexes.
The high-affinity IgE receptor (FcepsilonRI) blocks apoptosis in normal human monocytes.
- BiologyThe Journal of clinical investigation
- 2000
It is shown that ligation of the high-affinity IgE receptor (FcepsilonRI) on human monocytes from nonatopic individuals markedly reduces apoptosis induced by serum deprivation or by CD95/Fas ligation, and mediates signals preventing monocyte apoptosis directly by increasing the levels of Bcl-2 and BCl-xL, and indirectly by means of TNF-alpha in an autocrine and paracrine fashion.