The central role of FcεRI in allergy

@article{vonBubnoff2003TheCR,
  title={The central role of Fc$\epsilon$RI in allergy},
  author={Dagmar von Bubnoff and Natalija Novak and Stefan Kraft and Thomas Bieber},
  journal={Clinical and Experimental Dermatology},
  year={2003},
  volume={28}
}
The high‐affinity receptor for immunoglobulin E (IgE), FcεRI, plays a central role in the initiation and control of atopic allergic inflammation. On mast cells and basophils, the function of the receptor is well known and constitutes cellular degranulation and the release of various mediators. FcεRI on antigen‐presenting cells (APCs), however, does not lead to degranulation of preformed granula, but has different functions: signal transduction pathways like the activation of NF‐κB are initiated… 
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