The central region of Gadd45 is required for its interaction with p21/WAF1.

@article{Zhao2000TheCR,
  title={The central region of Gadd45 is required for its interaction with p21/WAF1.},
  author={Huiwu Zhao and Songmu Jin and Michael J. Antinore and Florin D. Lung and Feiyue Fan and Patricia Blanck and Peter Paul Roller and Albert J. Fornace and Qimin Zhan},
  journal={Experimental cell research},
  year={2000},
  volume={258 1},
  pages={
          92-100
        }
}
Cell cycle arrest represents an important response to genotoxic stress and the tumor suppressor p53 has been described to act as a critical effector in this biological event. Upon stress, p53 becomes transcriptionally active and up-regulates the transcription of downstream effector genes, which contain p53 recognition sites in their regulatory regions. Among the genes activated are p21 and GADD45, each of which independently exhibits growth-suppressive activity. The Gadd45 protein has been… CONTINUE READING
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