The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.

@article{Mehta2011TheCN,
  title={The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.},
  author={Shwetal Mehta and Emmanuelle Huillard and Santosh Kesari and C{\'e}cile L. Maire and Diane Golebiowski and Emily P. Harrington and John A. Alberta and Michael F. Kane and Matthew Theisen and Keith L Ligon and David H Rowitch and Charles Dean Stiles},
  journal={Cancer cell},
  year={2011},
  volume={19 3},
  pages={359-71}
}
High-grade gliomas are notoriously insensitive to radiation and genotoxic drugs. Paradoxically, the p53 gene is structurally intact in the majority of these tumors. Resistance to genotoxic modalities in p53-positive gliomas is generally attributed to attenuation of p53 functions by mutations of other components within the p53 signaling axis, such as p14(Arf), MDM2, and ATM, but this explanation is not entirely satisfactory. We show here that the central nervous system (CNS)-restricted… CONTINUE READING
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Tumours of the Central Nervous System, Fourth Edition (Lyon: IARC Press)

  • P. Kleihues, W. K. Cavenee
  • 2007
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