The central nervous system is a viral reservoir in simian immunodeficiency virus-infected macaques on combined antiretroviral therapy: A model for human immunodeficiency virus patients on highly active antiretroviral therapy

@article{Clements2005TheCN,
  title={The central nervous system is a viral reservoir in simian immunodeficiency virus-infected macaques on combined antiretroviral therapy: A model for human immunodeficiency virus patients on highly active antiretroviral therapy},
  author={Janice E. Clements and Ming Li and Lucio Gama and Brandon T. Bullock and Lucy M. Carruth and Joseph L Mankowski and M. Christine Zink},
  journal={Journal of NeuroVirology},
  year={2005},
  volume={11},
  pages={180-189}
}
This study used a simian immunodeficiency virus (SIV)-macaque model to determine whether virus persists in the central nervous system (CNS) of human immunodeficiency virus (HIV)-infected individuals in which plasma viral load has been suppressed by highly active antiretroviral therapy. SIV-infected macaques were treated with two reverse transcriptase inhibitors: PMPA (9-R-(2-phosphonomethoxypropyl)adenine), which does not cross the blood-brain barrier, and FTC (beta-2′,3′-dideoxy-3′-thia-5… CONTINUE READING
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