The central nervous system as a site of action for the coronary vasoconstrictor effect of digoxin.

@article{Garan1974TheCN,
  title={The central nervous system as a site of action for the coronary vasoconstrictor effect of digoxin.},
  author={Hasan Garan and Thomas W. Smith and Wm. John Powell},
  journal={The Journal of clinical investigation},
  year={1974},
  volume={54 6},
  pages={1365-72}
}
Digitalis is known to have a vasoconstrictor effect in the coronary circulation. Recent studies have demonstrated that the coronary vasoconstrictor effects of acetylstrophanthidin and digoxin are neurally mediated via alpha adrenergic fibers. In the present study, experiments were done in 20 dogs anesthetized with chloralose and urethane to study the… CONTINUE READING