The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection.

@article{Clements2002TheCN,
  title={The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection.},
  author={Janice E. Clements and Tahar Babas and Joseph L Mankowski and K M Suryanarayana and Michael J. Piatak and Patrick M. Tarwater and Jeffrey D Lifson and M. Christine Zink},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={186 7},
  pages={905-13}
}
Latent reservoirs of human immunodeficiency virus (HIV) present significant challenges for eradicating HIV from infected persons, particularly reservoirs in the brain established during acute infection. A simian immunodeficiency virus (SIV)/macaque model of HIV dementia was used to show that viral DNA levels in the brain remained at constant levels from acute through asymptomatic infection, despite significant down-regulation of viral RNA in the brain after the acute phase of infection. Viral… CONTINUE READING
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