The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease

@inproceedings{Chen2014TheCM,
  title={The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease},
  author={Ko-Fan Chen and Bernard Possidente and David A. Lomas and Damian C Crowther},
  booktitle={Disease models & mechanisms},
  year={2014}
}
Circadian behavioural deficits, including sleep irregularity and restlessness in the evening, are a distressing early feature of Alzheimer's disease (AD). We have investigated these phenomena by studying the circadian behaviour of transgenic Drosophila expressing the amyloid beta peptide (Aβ). We find that Aβ expression results in an age-related loss of circadian behavioural rhythms despite ongoing normal molecular oscillations in the central clock neurons. Even in the absence of any… CONTINUE READING
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