The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.

@article{Jossin2004TheCF,
  title={The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.},
  author={Yves Jossin and Nina Ignatova and Thomas Hiesberger and Joachim Herz and Catherine Lambert de Rouvroit and Andre M Goffinet},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 2},
  pages={514-21}
}
Reelin is a large extracellular protein that controls cortical development. It binds to lipoprotein receptors very-low-density lipoprotein receptor and apolipoprotein-E receptor type 2, thereby inducing phosphorylation of the adapter Dab1. In vivo, Reelin is cleaved into three fragments, but their respective function is unknown. Here we show the following: (1) the central fragment is necessary and sufficient for receptor binding in vitro and for Dab1 phosphorylation in neuronal cultures; (2… CONTINUE READING
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