The central executioners of apoptosis: caspases or mitochondria?

@article{Green1998TheCE,
  title={The central executioners of apoptosis: caspases or mitochondria?},
  author={Douglas R Green and Guido Kroemer},
  journal={Trends in cell biology},
  year={1998},
  volume={8 7},
  pages={267-71}
}
Apoptosis is a type of cell death whose morphological appearance relies on the activation of caspase-family cysteine proteases. Recently, it has become clear that inhibition of caspases does not always prevent irreversible loss of cellular function, although it does prevent the acquisition of apoptotic morphology. Alterations in mitochondrial membrane structure and function can occur in a caspase-independent fashion and have a higher predictive value for cell death than caspase activation. Here… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 277 extracted citations

Similar Papers

Loading similar papers…