The central executioners of apoptosis: caspases or mitochondria?

  title={The central executioners of apoptosis: caspases or mitochondria?},
  author={Douglas R Green and Guido Kroemer},
  journal={Trends in cell biology},
  volume={8 7},
Apoptosis is a type of cell death whose morphological appearance relies on the activation of caspase-family cysteine proteases. Recently, it has become clear that inhibition of caspases does not always prevent irreversible loss of cellular function, although it does prevent the acquisition of apoptotic morphology. Alterations in mitochondrial membrane structure and function can occur in a caspase-independent fashion and have a higher predictive value for cell death than caspase activation. Here… CONTINUE READING
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