The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer.

@article{Peak2003TheCD,
  title={The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer.},
  author={Mandy M. Peak and Janeen L. Arbuckle and Karla K Rodgers},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 20},
  pages={
          18235-40
        }
}
  • Mandy M. Peak, Janeen L. Arbuckle, Karla K Rodgers
  • Published in
    The Journal of biological…
    2003
  • Biology, Medicine
  • RAG1 and RAG2 initiate V(D)J recombination by introducing DNA double strand breaks between each selected gene segment and its bordering recombination signal sequence (RSS) in a two-step mechanism in which the DNA is first nicked, followed by hairpin formation. The RSS consists of a conserved nonamer and heptamer sequence, in which the latter borders the site of DNA cleavage. A region within RAG1, referred to as the central domain (residues 528-760 of 1040 in the full-length protein), has been… CONTINUE READING

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    Citations

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