The central cannabinoid receptor inactivation suppresses endocrine reproductive functions.

  title={The central cannabinoid receptor inactivation suppresses endocrine reproductive functions.},
  author={Tibor Wenger and Catherine A. Ledent and Val{\'e}r J Csernus and Ida Gerendai},
  journal={Biochemical and biophysical research communications},
  volume={284 2},
The function of central cannabinoid (CB1) receptor was investigated in the regulation of the pituitary-gonad axis in CB1 receptor knockout male mouse. Serum luteinizing hormone (LH) and testosterone (T) levels and basal T secretion in vitro of testes were significantly decreased in mutant (CB1-/-) mice. The receptor agonist, anandamide (ANA), suppressed LH and T secretion in wild type (CB1+/+) mice but had no effect in receptor inactivated animals. The results are the first descriptions… CONTINUE READING


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