The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.

@article{Waksman1999TheCC,
  title={The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.},
  author={Y Waksman and James M. Olson and Sue Carlisle and Guy A. Cabral},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={288 3},
  pages={1357-66}
}
Upon activation, brain microglial cells release proinflammatory mediators, such as nitric oxide (NO), which may play an important role in the central nervous system antibacterial, antiviral, and antitumor activities. However, excessive release of NO has been postulated to elicit immune-mediated neurodegenerative inflammatory processes and to cause brain injury. In the present study, the effect of cannabinoids on the release of NO from endotoxin/cytokine-activated rat cortical microglial cells… CONTINUE READING
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