The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice.

@article{Pang2011TheCC,
  title={The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice.},
  author={Zhen Pang and Nancy Wu and Weiguang Zhao and David C Chain and Erica Schaffer and Xin Zhang and Preeti Yamdagni and Vaseem A Palejwala and Chunpeng Fan and Sarah G Favara and Holly M Dressler and Kyriakos D Economides and Daniel Weinstock and Jean S Cavallo and Souad Naimi and A Galzin and Etienne Guillot and Marie-Pierre Pruniaux and Michael J Tocci and H. Greg Polites},
  journal={Obesity},
  year={2011},
  volume={19 10},
  pages={1923-34}
}
Cannabinoid receptor CB1 is expressed abundantly in the brain and presumably in the peripheral tissues responsible for energy metabolism. It is unclear if the antiobesity effects of rimonabant, a CB1 antagonist, are mediated through the central or the peripheral CB1 receptors. To address this question, we generated transgenic mice with central nervous system (CNS)-specific knockdown (KD) of CB1, by expressing an artificial microRNA (AMIR) under the control of the neuronal Thy1.2 promoter. In… CONTINUE READING
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