The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase.

@article{Deutsch2001TheCU,
  title={The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase.},
  author={Dale G. Deutsch and Sherrye T. Glaser and Jeffrey M. Howell and Jeffrey S. Kunz and Robyn A Puffenbarger and Cecilia J. Hillard and Nada A. Abumrad},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 10},
  pages={6967-73}
}
Anandamide is an endogenous compound that acts as an agonist at cannabinoid receptors. It is inactivated via intracellular degradation after its uptake into cells by a carrier-mediated process that depends upon a concentration gradient. The fate of anandamide in those cells containing an amidase called fatty-acid amide hydrolase (FAAH) is hydrolysis to arachidonic acid and ethanolamine. The active site nucleophilic serine of FAAH is inactivated by a variety of inhibitors including… CONTINUE READING
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